Becky A
At which cold sore stage was AlgalAid first applied?: Prodromal
If applied at the prodromal stage, did AlgalAid prevent the outbreak?: Yes
On what date did you first notice the cold sore? : 2/4/10
What time was it?: 9:54 AM
On what date was it healed?: SAME DAY!
What time was it?: 1:10 PM
How often do you suffer from cold sores?: Twice a year
What is your age?: 51-60
How would you describe your pigmentation if 5 is dark and 1 is light?: 2
Gender?: Female
Any comments? Please include any additional herbs or remedies taken, side effects or your general impression of Algalaid.: FANTASTIC!!!! NOTHING COULD POSSIBLY BE BETTER!!!! ABSOLUTELY WORKED IN A REMARKABLE TIMEFRAME-LESS THAN 3 HOURS!!!!! NEVER WENT PAST THE \”TINGLING\” STAGE. ONLY HAD TO APPLY A SMALL AMOUNT 3 TIMES. MAY HAVE BEEN ABLE TO GET BY WITH JUST 2 ADMINISTRATIONS, DID 3 JUST TO MAKE SURE! I AM IN FRONT OF THE PUBLIC AS A HEALTH FOODS DEMONSTRATOR AND CANNOT AFFORD TO HAVE A SORE ON MY MOUTH SHOWING!! I\’VE NEVER SEEN ANTHING WORK SO FAST IN ALL OF MY LIFE!! IT\’S SIMPLY AMAZING!! DID NOTHING ELSE FOR IT EXCEPT USE THE ALGALAID!! RECEIVED MY SAMPLE THRU SIGNING UP AT THE SOHO CONVENTION IN ORLANDO, FL IN 12/09. THANKS!!

Karen A
At which cold sore stage was AlgalAid first applied?: Prodromal
If applied at the prodromal stage, did AlgalAid prevent the outbreak?: Yes
On what date did you first notice the cold sore? : 2-6-2010
What time was it?: 8:00 am
On what date was it healed?: 2-8-2010
What time was it?: Gone when I woke up
How often do you suffer from cold sores?:  Twice a year
What is your age?: 61-70
How would you describe your pigmentation if 5 is dark and 1 is light?: 3
Gender?: Female
Any comments?  Dryness around the application area. This product seemed to work as good or better than prescription remedies I have tried in the past.

AlgalAid® is an FDA monograph compliant treatment for cold sores and fever blisters containing <1% menthol as an active topical analgesic ingredient. This sample of AlgalAid contains 25% Blue Moon Marine Botanical Extract at ph 5.6, deionized water, emu oil (10%), pure grain alcohol, kosher glycerin, organic aloe vera, iota carrageenan, allantoin, stevia, rosemary oil extract, potassium sorbate, sodium benzoate and citric acid.

This extract is formulated for this batch of AlgalAid based on the in vitro analysis of the constituent plants against HSV1 Strain F (#VR-733.) These plants include 4 spp of marine red algae collected from Lower Cook Inlet in Alaska and the Strait of Juan de Fuca in British Columbia. This dynamic approach to cold sore treatment formulation allows us to utilize the natural diversity of antiviral compounds found in these plants to confront the diversity of herpetic pathogens.

The antiviral action of the sulfated polysaccharide cell wall constituents has been documented since 1958. They are involved in ion exchange, cell wall rigidity manipulation, in forming highly specific secondary pit connections between cells and in the cellular recognition required to guide a complex fertilization mechanism of non-motile male gametes. The polysaccharides are a complex mix of galactans with structures based on linear chains of  carrageenans and agars with branching substitutions of sulfate groups. 

There was an early understanding that these compounds present a high density negative charge with sulfate residues that fit and interact with the cationic charged domains of the viral glycoproteins. It has since been found that, in the case of HSV, there are five viral glycoproteins involved in the binding, attachment and fusion of HSV with the host cell wall. The polysulfate’s main effect is on the specific interaction between the viruses ‘gC’ glycoprotein and heparin sulfate receptors on the host cell surface and variations of this attachment.

These compounds have been reported[1] to show invitro efficacy for a wide spectrum of enveloped viruses such as retroviruses (HIV1&2), herpes simplex virus (HSV 1&2), varicella zoster virus (VZV), human cytomegalovirus (HCMV), human papilloma virus (Hpv), pseudorabis virus (PrV), flaviviruses (dengue virus type 2), poxviruses (vaccinia virus), hepdanaviruses (hepatitis B virus (HBV)), orthomoxoviruses (influenza A virus (inf A)) and others.

There is also a high selectivity of viral action in cell cultures, as low as .01 to 1 µg/mL with very low cytotoxicity. The serial passage in cell cultures of viruses in the presence of increasing concentrations of sulfated polysaccharides show these compounds to be slow, though existent, inducers of viral drug resistance, but at much lower rates that other antivirals. The sulfated polysaccharides found in AlgalAid have been found to be inhibitory to acyclovir (ACV) resistant strains of HSV1. Several carrageenans have recently been the subject of phase 3 clinical trials in Africa and the red algal derived protein, griffithsin, is the leading candidate as a second generation HIV microbicide.

This batch of AlgalAid contains the following plants and life history phases: Turnerella mertensiana- gametic , Neodilsea borealis- tetrasporic, Cryptosiphonia woodii -gametic Constantinea rosa marina- carposporic. These particular algal species have been used by compounding pharmacists in Alaska for over 25 years without adverse incident.  Our extraction techniques employ sonification to disintegrate the cell walls and centrifugation to separate and isolate active fractions. 

Ongoing laboratory quality assurance determines the lack of cytotoxicity and adequate antiviral inhibitory concentrations for each batch and well as GMP QC requirements for  microbial, pesticide and heavy metal contamination.

Given the variation of the plants we incorporate in the extracts, their life history phases and the suite of active compounds found in each whole plant extract, Blue Moon Marine conducts  ongoing randomized, double blind, active controlled, clinical surveys. Current results are available upon request.


[1]       Damonte, Elsa B.; et al, Sulfated Seaweed Polysaccharides as Antiviral Agents. Current Medicinal Chemistry, 2004, 11, 2399- 2419

To whom it may concern,
>
> Thank you! I have Rosacea and recently had an outbreak. I do not like using the medication prescribed to treat Rosacea so out of desperation I decided to apply AlgalAid to the affected area. Wow!!! I saw a dramatic difference overnight. I have been using it for over 1 week and the results are amazing. I know this product is not used to treat Rosacea, but I just had to share this with you. Maybe you can help others with this problem.
>
> Sincerley,
> C G

SOS

acidocean011

 

Some good citizens of Homer got together last weekend to draw attention to increasing oceanic acidification and the dire consequences it implies. Here is a link to  those who sponsored the event. Yes, we were part of the ‘O’.